![]() Toolbox functions for deconvolution, semicompartmental modeling, nonparametric superposition and crossover design.Īutomatic determination of initial estimates.Īnalysis using general linear modeling approaches, including bioequivalence tests as appropriate.īuilt-in scripting language (Pharsight Modeling Language or PML). Pharmacokinetics (PK) and pharmacodynamics (PD) of MCLA-128 have been evaluated in preclinical studies in cynomolgus monkeys and mice. The NCA, PK/PD modeling tools, and statistical analysis capabilities in WinNonlin are used to support many different types of studies at Everest. Introduction MCLA-128 is a bispecific monoclonal antibody targeting the HER2 and HER3 receptors. Powerful data management tools allow users to append worksheets, change properties and/or transform columns, add BQL Rules or map cross product worksheets, as well as filter, join, merge, pivot, rank, split, and stack data. Everest uses Phoenix WinNonlin 8.1 to conduct pharmacokinetic (PK) and pharmacodynamic (PD) analysis, modelling and simulation, and non-compartmental analysis (NCA). Units definition and conversions, including the ability to specify preferred output units, units for a dosing regimen, and unit conversions. Three methods of AUC calculation: linear trapezoidal, linear/log trapezoidal, and linear up/log down.ĭescriptive statistics, including weighted descriptive statistics. Perform noncompartmental analysis of both blood and urine data using methods for rich or sparse datasets in a single run.
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